Discriminating Tumor Deposits From Metastatic Lymph Nodes in Rectal Cancer: A Pilot Study Utilizing Dynamic Contrast-Enhanced MRI

作者：Xue-han Wu, Yu-Tao Que, Xinyue Yang, Zi-qiang Wen, Yu-Ru Ma, Zhi-wen Zhang, Quan-meng Liu, Wen-jie Fan, Li Ding, Yuejiao Lang, Yun-zhu Wu, Jianpeng Yuan, Shenping Yu, Yi-Yan Liu, Yan Chen · 发表于：Korean Journal of Radiology · 年份：2025 · DOI：10.3348/kjr.2024.0767 · 被引用次数：6 · 研究领域：Colorectal Cancer Surgical Treatments、Radiomics and Machine Learning in Medical Imaging、MRI in cancer diagnosis

Objective: To evaluate the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) in differentiating tumor deposits (TDs) from metastatic lymph nodes (MLNs) in rectal cancer.Materials and Methods: A retrospective analysis was conducted on 70 patients with rectal cancer, including 168 lesions (70 TDs and 98 MLNs confirmed by histopathology), who underwent pretreatment MRI and subsequent surgery between March 2019 and December 2022.The morphological characteristics of TDs and MLNs, along with quantitative parameters derived from DCE-MRI (K trans , kep, and ve) and DWI (ADCmin, ADCmax, and ADCmean), were analyzed and compared between the two groups.Multivariable binary logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the diagnostic performance of significant individual quantitative parameters and combined parameters in distinguishing TDs from MLNs.Results: All morphological features, including size, shape, border, and signal intensity, as well as all DCE-MRI parameters showed significant differences between TDs and MLNs (all P < 0.05).However, ADC values did not demonstrate significant differences (all P > 0.05).Among the single quantitative parameters, ve had the highest diagnostic accuracy, with an area under the ROC curve (AUC) of 0.772 for distinguishing TDs from MLNs.A multivariable logistic regression model incorporating short axis, border, ve, and ADCmean improved diagnostic performance, achieving an AUC of 0.833 (P =...