Helicobacter pylori infection is linked to metabolic dysfunction and associated steatotic liver disease: A large cross-sectional study

作者：Lin Ye, Kai Yan, Zijian Tian, Zhihua Xiao, Ru-Yi Xie, Zhengyuan Xie, Liyuan Tao · 发表于：World Journal of Gastroenterology · 年份：2025 · DOI：10.3748/wjg.v31.i13.102563 · 被引用次数：11 · 研究领域：Helicobacter pylori-related gastroenterology studies、Diet, Metabolism, and Disease、Microbial Metabolites in Food Biotechnology

BACKGROUND Helicobacter pylori (H. pylori ), a globally widespread pathogen affecting half of the global population, has been increasingly implicated in metabolic disorders, including obesity, dyslipidemia, and metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD is a common condition, impacting nearly one in four adults globally. It also shares significant pathophysiological links with metabolic syndrome. Despite the fact that mechanistic hypotheses (such as oxidative stress and inflammation) have been proposed to explain these relationships, large-scale studies comprehensively assessing multifactorial metabolic associations are lacking. We proposed that H. py lori infection may independently correlate with unfavorable metabolic profiles and the presence of MASLD among adults in a large cohort. AIM To investigate the associations of H. pylori infection with obesity, glucose, lipids, blood pressure, and MASLD in Chinese adults. METHODS This study included 28624 adults recruited from the Physical Examination Center at Nanchang University's Second Affiliated Hospital. The 13C-urea breath test was used to identify H. pylori infection, while abdominal ultrasound was employed for MASLD diagnosis. The relationships between H. pylori infection and metabolic factors were analyzed via multivariate logistic regression. RESULTS The overall H. pylori infection incidence was 26.8%, with higher rates observed in older adults (≥ 70 years: 26.1% vs 18-29 years: 24.6%, P &l...