Occupational Exposure to Disinfectants and Risk of Incident Cardiovascular Disease among US Nurses: The Nurses’ Health Study II

作者：Yixin Wang, Orianne Dumas, Raphaëlle Varraso, Yang Sun, Janet W. Rich‐Edwards, JoAnn E. Manson, Kenneth J. Mukamal, Yu Zhang, Carlos A. Camargo, Carmen Messerlian · 发表于：Environmental Health Perspectives · 年份：2025 · DOI：10.1289/ehp14945 · 被引用次数：4 · 研究领域：Medical Device Sterilization and Disinfection、Occupational exposure and asthma、Infection Control and Ventilation

BACKGROUND: Exposure to certain chemicals in disinfectants has been associated with vascular dysfunction in toxicological studies, but the association between disinfectant exposure and clinical cardiovascular disease (CVD) remains unclear. OBJECTIVE: The aim of this study was to evaluate the association between occupational exposure to disinfectants and subsequent risk of CVD among US nurses. METHODS: We included 75,675 participants from The Nurses' Health Study II who maintained a nursing job and reported data on occupational disinfectant exposure. We estimated hazard ratios (HR) and 95% confidence intervals (CIs) of incident CVD, including coronary heart disease (CHD) and stroke, using Cox proportional hazard models comparing job types and general disinfection tasks between participants. We also used a job-task-exposure matrix to evaluate the risk of CVD by frequency of cleaning/disinfection tasks and exposure levels of seven specific disinfectants (formaldehyde, glutaraldehyde, hypochlorite bleach, hydrogen peroxide, alcohol, quaternary ammonium compounds, and enzymatic cleaners). RESULTS: ; 95% CI: 1.04, 1.40), in comparison with women who never used disinfectants. The highest CVD risk was observed among nurses using disinfectants or spray or aerosol products 4-7 d/wk and those exposed to the highest levels of the seven specific disinfectants listed above. CONCLUSION: Exposure to disinfectants in real-world health care settings was associated with a higher risk of CVD, in...