Clinical Study of Post‐Chemotherapy Cardiotoxicity in Breast Cancer Patients Based on Ultrasound Radiomics

作者：Caiyun Xia, Shutian Wu, Yuxin Zhong, Jiangtao Wang, Alin Yao, Biaohu Liu · 发表于：Echocardiography · 年份：2025 · DOI：10.1111/echo.70136 · 被引用次数：3 · 研究领域：Chemotherapy-induced cardiotoxicity and mitigation、Ultrasound and Hyperthermia Applications、Cardiac Imaging and Diagnostics

ABSTRACT Purpose The aim of this study is to develop and validate a combined model based on ultrasound radiomics to detect cardiotoxicity after chemotherapy in patients with breast cancer. Methods In this paper, we included 208 patients with breast cancer diagnosed pathologically and after chemotherapy, of whom had high‐quality echocardiographic images; among them, 105 cases experienced cardiotoxicity, while 103 cases did not, which were divided into a training set and a validation set using a wholly randomized method according to a ratio of 7:3. Then, the left ventricular myocardium in the parasternal long‐axis view of echocardiography was manually traced, the myocardial features of each image were extracted and filtered, and then a radiomics model was established; lastly, we plotted the receiver operating characteristic (ROC) curve; calculated the area under the curve (AUC); and assessed the diagnostic performance of the model. Results The AUC of the combined model in the training set was 0.88 (95%CI,0.828–0.936), which was higher than the clinical model at 0.73 (95%CI,0.646–0.807) and the radiomics model at 0.84 (95%CI,0.774–0.903). In the validation set, the AUC of the combined model was 0.87 (95%CI,0.783–0.959), which was higher than the clinical model at 0.75 (95%CI,0.631–0.877) and the radiomics model at 0.81 (95%CI,0.698–0.917). The combined model of the training group and the validation group had statistical significance compared to both the clinical model and the ra...