Per- and Polyfluoroalkyl Ether Acid (PFEA) Concentrations in Indoor Dust are Higher in Homes Closer to a Fluorochemical Manufacturing Facility

作者：Susie Proctor, Jane A. Hoppin, Sharon Zhang, Heather M. Stapleton, Detlef R.U. Knappe, Nadine Kotlarz · 发表于：Environmental Science & Technology · 年份：2025 · DOI：10.1021/acs.est.4c07043 · 被引用次数：18 · 研究领域：Per- and polyfluoroalkyl substances research、Air Quality and Health Impacts、Atmospheric chemistry and aerosols

Concentrations of 48 per- and polyfluoroalkyl substances (PFAS) were measured in settled dust samples from 65 homes of GenX Exposure Study participants residing near a fluorochemical manufacturing facility in North Carolina. Eight PFAS [perfluoro(3,5-dioxahexanoic) acid (aka PFO2HxA), perfluoro-2-(perfluoromethoxy)propanoic acid (PMPA), perfluoro-2-ethoxypropanoic acid (PEPA), 6:2 fluorotelomer phosphate diester (6:2 diPAP), 6:2/8:2 fluorotelomer phosphate diester (6:2/8:2 diPAP), perfluoropropanoic acid (PFPrA), perfluorodecanesulfonic acid (PFDS), and 2-( N -ethyl-perfluorooctanesulfonamido)acetic acid (N-EtFOSAA)] were detected in >90% of the dust samples. Dust concentrations of six per- and polyfluoroalkyl ether acids (PFEAs) produced at the facility (PEPA, PMPA, perfluoro-2-methoxyacetic acid (PFMOAA), PFO2HxA, hexafluoropropylene oxide dimer acid (HFPO–DA aka GenX), and ethanesulfonic acid, 2-[1-[difluoro(1,2,2,2-tetrafluoroethoxy)methyl]-1,2,2,2- tetrafluoroethoxy]-1,1,2,2-tetrafluoro- (Nafion byproduct 2) were significantly negatively associated with home distance from the facility. Homes closer to the facility had higher summed mass concentrations of 12 targeted PFEAs ( ∑ 12 PFEAs ) but not higher ∑ 48 PFAS . Trifluoroacetic acid (TFA), an ultrashort chain PFAS, and three diPAPs (8:2/6:2 diPAP, 6:2 diPAP, and 8:2 diPAP) were the major contributors to ∑ 48 PFAS, and these compounds did not show relationships with distance. Based on our previous findings associating PF...