Saline nasal irrigation for acute sinusitis (SNIFS II): a randomised controlled pilot trial with nested process evaluation

作者：Roderick P Venekamp, Ben Ainsworth, Tammy Thomas, Beth Stuart, Joanna Slodkowska‐Barabasz, Fiona Mowbray, Christopher Butler, Nick Francis, Samantha Richards-Hall, Anthony Harnden, Alastair D Hay, Claire Hopkins, Michael Moore, Lucy Yardley, Theo Verheij, Shihua Zhu, Paul Little · 发表于：BJGP Open · 年份：2025 · DOI：10.3399/bjgpo.2024.0307 · 被引用次数：2 · 研究领域：Sinusitis and nasal conditions、Nasal Surgery and Airway Studies、Dental Research and COVID-19

Background Despite having marginal beneficial effects, antibiotics are routinely prescribed in adults with acute sinusitis. Alternative interventions for this common condition are urgently needed. Aim To assess the feasibility and acceptability of saline nasal irrigation for acute sinusitis. Design & setting Randomised controlled pilot trial with nested process evaluation in 24 English general practices between October 2019 and May 2021. Method Participants were randomised to advice to high-volume hypertonic saline nasal irrigation with a delayed antibiotic prescription or usual care. Feasibility outcomes included recruitment and follow-up rates, adherence, and acceptability of the intervention. Results Of those invited, n = 81/107 (76%) consented and were randomised (42 intervention, 39 usual care). Two participants were excluded owing to ineligibility. Antibiotic prescribing strategies were recorded at baseline for n = 79/79 (100%), with no or delayed antibiotics prescribed in 60% ( n = 24/40) of the saline group versus 38% ( n = 15/39) of the usual care group. At follow-up, 80% ( n = 63/79) of participants recorded whether they consumed antibiotics or not. Among those from the intervention group who returned a symptom diary, 96% ( n = 22/23) and 65% ( n = 15/23) reported using saline nasal irrigation during the first and second week, respectively. Semi-structured interviews with 16 participants revealed that most were positive about trial participation and viewed salin...