Effects of Early Midlife Ovarian Removal on Medial Temporal Lobe Gray Matter Volume and Recognition Memory

作者：Alana Brown, Nicole Gervais, Laura Gravelsins, Shuchun Zhao, Annie Duchesne, Jenny Rieck, Anna Mouzenian, Noelia Calvo, Negar Mazloum‐Farzaghi, Rosanna K. Olsen, Morgan D. Barense, Zhuo Shao, Marcus Q. Bernardini, Michelle Jacobson, M. Natasha Rajah, Cheryl Grady, Gillian Einstein · 发表于：Hippocampus · 年份：2025 · DOI：10.1002/hipo.70012 · 被引用次数：6 · 研究领域：Menopause: Health Impacts and Treatments、Cognitive Abilities and Testing、Functional Brain Connectivity Studies

Early midlife bilateral salpingo-oophorectomy (BSO) is associated with greater Alzheimer's disease risk compared to spontaneous/natural menopause. Previously, we found that participants with BSO had lower volume in the hippocampal dentate gyrus and cornu ammonis 2/3 composite subfield (DG-CA2/3). We sought to extend those hippocampal subfield findings by assessing whether BSO affected volumes along the anteroposterior hippocampal axis, anterolateral entorhinal cortex, and perirhinal cortex subregions (Brodmann area (BA) 35 and 36). We also correlated volumes with key demographic and wellbeing-related factors (age, depressive mood, education), hormone therapy characteristics, and recognition memory performance. Early midlife participants with BSO (with and without 17β-estradiol therapy (ET)) and age-matched control participants with intact ovaries (AMC) completed high-resolution T2-weighted structural magnetic resonance imaging (MRI). Medial temporal lobe volumes and Remember-Know task recognition memory performance were compared between groups-BSO (n = 23), BSO + ET (n = 28), AMC (n = 34) using univariate analyses. Multivariate Partial Least Squares (PLS) analyses were used to examine how volumes related to demographic and wellbeing-related factors, as well as hormone therapy characteristics. Relative to BSO + ET, BSO had lower posterior hippocampal and DG-CA2/3 volumes but greater perirhinal BA 36 volumes. Compared to age, depressive mood, and education, ET was the strongest...