Comprehensive Review on Application Progress of Marine Collagen Cross-Linking Modification in Bone Repairs

作者：Xiaofei Zhai, X. Geng, Wenjun Li, Hongli Cui, Yunqing Wang, Song Qin · 发表于：Marine Drugs · 年份：2025 · DOI：10.3390/md23040151 · 被引用次数：17 · 研究领域：Bone Tissue Engineering Materials、Collagen: Extraction and Characterization、Periodontal Regeneration and Treatments

Bone tissue injuries are a significant health risk, and their repair is challenging. While various materials have potential for bone repair, issues like sourcing and immune rejection limit their use. Marine-derived collagen, abundant and free from religious and disease transmission concerns, is a promising biomaterial in bone tissue engineering. Cross-linking modification can enhance its mechanical properties and degradation rate, making it more suitable for bone repair. However, detailed analysis of cross-linking methods, property changes post-cross-linking, and their impact on bone repair is needed. This review examines marine collagen's modification methods, improved characteristics, and potential in bone tissue repair, providing a foundation for its effective use in bone tissue engineering.