Zirconium Metal–Organic Frameworks as Micromotors with Enzyme-like Activity for Glutathione Detection

作者：Xiaoqing Li, Gui Wang, Dongyang Zhou, Ziwei Lan, Feng Jiang, Dickon H. L. Ng, Jia Li · 发表于：Inorganic Chemistry · 年份：2025 · DOI：10.1021/acs.inorgchem.5c00494 · 被引用次数：7 · 研究领域：Metal-Organic Frameworks: Synthesis and Applications、Advanced Nanomaterials in Catalysis、Sulfur Compounds in Biology

Herein, we report a novel UiO-67-Co(bpy) 0.35 micromotor synthesized by a facile postsynthesis metalation via introducing cobalt salts ligated with 2,2′-bipyridine-5,5′dicarboxylic acid into UiO-67-bpy 0.35 framework. The Co 2+ active sites can decompose H 2 O 2 to generate bubbles to power UiO-67-Co(bpy) 0.35 . Meanwhile, the UiO-67-Co(bpy) 0.35 micromotor exhibits robust peroxidase-like activity through catalyzing H 2 O 2 to generate • OH under neutral conditions. Based on this, a sensing platform was constructed for the colorimetric detection of GSH. Due to the synergy of self-driven motion and excellent peroxide-like activity, UiO-67-Co(bpy) 0.35 micromotor can sensitively detect GSH with a low analytic limitation as 0.13 μM for GSH detection. This study provides a new sight of using the postsynthesis metalation method to prepare Zr(Co)-MOF micromotor for highly selective, sensitive, and facile detection of GSH.