Effect of amphetamines on blood pressure

作者：Magnus Chan, Jocelyn Joy Chan, James M Wright · 发表于：Cochrane Database of Systematic Reviews · 年份：2025 · DOI：10.1002/14651858.cd007896.pub4 · 被引用次数：2 · 研究领域：Forensic Toxicology and Drug Analysis、Substance Abuse Treatment and Outcomes、Attention Deficit Hyperactivity Disorder

BACKGROUND: Daily ingestion of amphetamines is common, as they are widely prescribed for attention-deficit hyperactivity disorder (ADHD) and other diagnoses. People also use amphetamines recreationally or in an attempt to boost cognitive or athletic performance. Amphetamines have the potential to increase blood pressure, and we do not know if the long-term benefits of daily amphetamine use outweigh the potential harms. OBJECTIVES: Primary: to quantify the changes in systolic and diastolic blood pressure in children and adults taking amphetamines, compared to placebo. Secondary: to quantify the changes in heart rate in children and adults taking amphetamines, compared to placebo; to quantify the number of withdrawals due to adverse effects of amphetamine, compared to placebo. SEARCH METHODS: We used the Cochrane Hypertension Specialized Register, CENTRAL, MEDLINE, Embase and two clinical trial registers, together with reference checking and contact with study authors to identify the studies included in the review. We imposed no restrictions on language, publication year or publication status. The latest search date was March 2023. SELECTION CRITERIA: Randomized controlled trials (RCTs) that compared the effects of daily oral amphetamines versus placebo on blood pressure. There were no restrictions on participants' age or gender. DATA COLLECTION AND ANALYSIS: We used standard methods expected by Cochrane. Primary outcomes were change in systolic and diastolic blood pressure (me...