Association of Ambient Air Pollution and Temperature Exposure with Placental Abruption: A Nested Case–Control Study Based on Live Birth Registrations

作者：Tong Wang, Wenzheng Zhou, Wenzheng Zhou, Han Liu, Zhan Yu, Dié Tang, Ying Guo, Chenran Yin, Dongyan Wu, Yayun Cao, Xi Ling, Huan Yang, Niya Zhou, Jia Cao, Wei Zhou, Wei Zhou, Qing Chen · 发表于：Environmental Health Perspectives · 年份：2025 · DOI：10.1289/ehp14714 · 被引用次数：5 · 研究领域：Air Quality and Health Impacts、Maternal and fetal healthcare、Pregnancy and preeclampsia studies

BACKGROUND: Placental abruption, a rare disorder of unclear etiology, lacks evidence to illustrate its relationship with exposure to air pollution and temperature. OBJECTIVE: This study aimed to investigate the association between exposure to ambient pollutants and temperatures and placental abruption to identify susceptible time windows and subpopulations. METHODS: ] and temperature were estimated using machine learning algorithms. A conditional logistic regression model analyzed associations of exposure to air pollution and temperature with placental abruption in five time windows (prepregnancy, the entire pregnancy, and each of the 3 trimesters). Stratification analyses were applied to examine potential modifiers including gravidity, parity, mothers' residential area (urban/rural), pandemic experience, and delivery season. RESULTS: ; 95% CI: 1.67, 8.08) in comparison with locally moderate temperatures (25th-75th percentile). Stratified analysis showed no statistical significances within the effect modifiers. DISCUSSION: , during pregnancy may be a substantial risk factor for placental abruption. https://doi.org/10.1289/EHP14714.