PREDICTORS AND OUTCOMES OF ACUTE KIDNEY INJURY IN INTRACEREBRAL HEMORRHAGE PATIENTS: EVIDENCE FROM A LARGE-SCALE NATIONAL DATABASE ANALYSIS

作者：Binbin Tian, Xuanhe Tang, Linling He, Junfen Cheng, Jian Wang, Silin Liang, Junde Mo, Chunbo Chen · 发表于：Shock · 年份：2025 · DOI：10.1097/shk.0000000000002577 · 被引用次数：6 · 研究领域：Intracerebral and Subarachnoid Hemorrhage Research、Neurosurgical Procedures and Complications

ABSTRACT: Background: Acute kidney injury (AKI) is a significant complication in patients with intracerebral hemorrhage (ICH). This study sought to explore the incidence, risk factors, and outcomes of AKI in ICH patients using a comprehensive national database. Methods: Data from the Nationwide Inpatient Sample database (2010-2019) were analyzed. This analysis compared demographics, comorbidities, complications, mortality, and healthcare utilization between ICH patients who developed AKI and those who did not. Multivariate logistic regression was used to identify risk factors for AKI and assess their impact on in-hospital outcomes. Results: The incidence of AKI among ICH patients increased from 10.7% in 2010 to 19.6% by 2019, yielding an overall incidence rate of 15%. Risk factors included, Black race, comorbidities (≥3), teaching hospital, and specific preexisting conditions such as congestive heart failure, coagulopathy, diabetes with chronic complications, fluid and electrolyte disorders, other neurological disorders, obesity, paralysis, chronic kidney disease excluding end-stage renal disease, peptic ulcer disease excluding bleeding, and weight loss. Conversely, female sex and elective admissions acted as protective factors. AKI-related in-hospital complications encompassed acute myocardial infarction, pneumonia, sepsis, cardiac arrest, respiratory failure, and mechanical ventilation. AKI was associated with higher in-hospital mortality (26.9% vs. 18.5%), prolonged hospit...