Phenotype-Based Classification of Obstructive Hypertrophic Cardiomyopathy Undergoing Myectomy

作者：Hao Cui, Hao Nie, Congrui Wang, Ningning Zhang, Yifan Wang, Wendao Liu, Siyuan Huang, Xiao Cheng, Hao Jia, Songren Shu, Mengxia Fu, Qian Zhao, Xiumeng Hua, Yuan Chang, Yunhu Song, Jiangping Song · 发表于：JACC Basic to Translational Science · 年份：2025 · DOI：10.1016/j.jacbts.2024.12.016 · 被引用次数：5 · 研究领域：Cardiomyopathy and Myosin Studies、Cardiac Structural Anomalies and Repair、Cardiovascular Function and Risk Factors

This study partitioned variables derived from clinical and pathological information in patients who received septal reduction therapy to identify obstructive hypertrophic cardiomyopathy subtypes. Subtype 1 was characterized by a high percentage of sarcomere mutation carriers and the highest interventricular septal thickness. Subtype 2 was featured by left atrial enlargement and a high percentage of patients with atrial fibrillation. Subtype 3 was characterized by a high left ventricular outflow tract gradient, serious inflammatory cell infiltration, and a high incidence of postoperative adverse events. This finding has been well replicated in 2 validation cohorts with short- and long-term follow-up.