On the Mechanism and Productivity of Single-Pulse Laser Fragmentation of Organic Curcumin Dispersions in a Continuous Flat Jet Flow-Through Reactor

作者：Tina Friedenauer, Maximilian Spellauge, Alexander Sommereyns, Christoph Rehbock, H. Huber, Stephan Barcikowski · 发表于：The Journal of Physical Chemistry C · 年份：2025 · DOI：10.1021/acs.jpcc.4c08643 · 被引用次数：6 · 研究领域：Petroleum Processing and Analysis、Laser-Ablation Synthesis of Nanoparticles、Phase Equilibria and Thermodynamics

Curcumin is a natural food additive (nutraceutical), whose bioavailability is impaired by low solubility, a drawback which may be overcome by particle size reduction. Microparticle (MP) laser fragmentation in liquids (LFL) is an emerging production method for sensitive, organic submicron particles (SMPs) and nanoparticles (NPs), as it is characterized by processing at minimal chemical degradation. However, the fragmentation mechanisms need to be understood to tune the MP-LFL process toward a high SMP yield. Therefore, we used pump-probe microscopy (PPM) to elucidate the dynamics of shockwave formation and cavitation bubble growth on single-curcumin particles in correlation with laser fluence utilizing a ps-pulsed laser at 1040 nm. We observed LFL to occur at a threshold fluence of 60 mJ cm –2 . Furthermore, we found a pressure buildup of 308 MPa within the particle, which exceeds the material’s tensile strength by one order of magnitude, hinting at strong contributions of photomechanical effects during curcumin MP-LFL. Consecutively, we examined the transfer to MP dispersions where concentration effects during MP-LFL were studied using a ps-pulsed laser at 532 nm and an optimized continuous flat jet (FJ) reactor, which is characterized by the ability to process particularly high concentrations of up to 1000 mg L –1 due to the low liquid layer thickness. An increased mass yield of SMP and NP (determined by UV–vis extinction spectroscopy and SEM) was found at high educt concent...