Interfacial Engineering Enhancing Electron Transfer of CaF 2 Nanoparticles for Periodontitis Treatment of Sonotherapy and Bone Resorption

作者：Qiuyu Liu, Yi Wang, Jin Huang, Xiangmei Liu, Congyang Mao, Chaofeng Wang, Yufeng Zheng, Hanpeng Liu, Khin Wee Lai, Zhaoyang Li, Shengli Zhu, Hui Jiang, Zhenduo Cui, Shuilin Wu · 发表于：ACS Nano · 年份：2025 · DOI：10.1021/acsnano.5c01112 · 被引用次数：23 · 研究领域：Bone Tissue Engineering Materials、Bacterial biofilms and quorum sensing、Ultrasound and Cavitation Phenomena

Conventional periodontitis treatments can be superseded by sonodynamic therapy. In this study, a Zn(OH)F/CaF 2 heterojunction was synthesized via a hydrothermal method, which exhibited good biocompatibility and antibacterial properties. The band gap decreased significantly after the formation of the heterojunction, thereby enhancing the internal electron transfer. In addition, after the bacteria contact with the material, the electrons of the electron transport chain turn to Zn(OH)F/CaF 2 and affect its steady state. Ultimately, H 2 O 2 in an inflammatory environment was used to react with Zn(OH)F/CaF 2 to facilitate electron transfer under the influence of ultrasound, ultimately enhancing the catalytic activity. Zn(OH)F/CaF 2 exhibits significant antibacterial efficacy against Porphyromonas gingivalis and Staphylococcus aureus . Trace elements Ca and Zn can promote tissue repair and osteogenic differentiation, resulting in less bone destruction and intact gingival tissue after periodontitis treatment. This sonodynamic therapy provides a rapid antibacterial, effective, and deep therapeutic method for treating periodontitis.