Unleashing the potential: 40 Hz multisensory stimulation therapy for cognitive impairment

作者：Xiao Chen, Zhongyue Lv, Guomin Xie, Cui Zhao, Yan Zhou, Fan Fu, Jiayi Li, Xiaoling Zhang, Feiteng Qi, Yifei Xu, Yifu Chen · 发表于：Journal of Central Nervous System Disease · 年份：2025 · DOI：10.1177/11795735251328029 · 被引用次数：6 · 研究领域：Neural dynamics and brain function、Neuroscience and Neural Engineering、EEG and Brain-Computer Interfaces

Cognitive impairment encompasses a spectrum of disorders marked by acquired deficits in cognitive function, potentially leading to diminished daily functioning and work capacity, often accompanied by psychiatric and behavioral disturbances. Alzheimer's disease (AD) and Post-stroke cognitive impairment (PSCI) are significant causes of cognitive decline. With the global population getting older, AD and PSCI are becoming major health concerns, underscoring the critical necessity for successful treatment options. In recent years, various non-invasive biophysical stimulation techniques, including ultrasound, light, electric, and magnetic stimulation, have been developed for the treatment of central nervous system diseases. Preliminary clinical studies have demonstrated the feasibility and safety of these techniques. This review discuss the impact of 40 Hz multisensory stimulation on cerebral function, behavioral outcomes, and disease progression in both animal models and individuals exhibiting cognitive deficits, such as AD and PSCI. Furthermore, it summarizes the potential neural pathways involved in this therapeutic modality by synthesizing evidence from a variety of studies within the field. Subsequently, it evaluates the existing constraints of this technique and underscores the potential advantages of 40 Hz multisensory stimulation therapy for individuals with cognitive deficits, with the goal of enhancing the management and care of AD and PSCI.