Independent risk factors for placental abruption: a systematic review and meta-analysis

作者：Dexin Chen, Xuelin Gao, Tingyue Yang, Xin Xing, Guohua Wang, Hong Wang, Rongxia He, Min Liu · 发表于：BMC Pregnancy and Childbirth · 年份：2025 · DOI：10.1186/s12884-025-07482-7 · 被引用次数：18 · 研究领域：Maternal and fetal healthcare、Pregnancy and preeclampsia studies、Reproductive Health and Contraception

BACKGROUND: Placental abruption is one of the most severe complications during pregnancy, and its associated risk factors remain incompletely understood and somewhat controversial. METHODS: This study conducted a systematic search of the PubMed, Embase, Cochrane, Web of Science, and Scopus databases to collect literature related to placental abruption, with a cutoff date of July 30, 2024. RESULTS: A total of 54 observational studies were included, covering 7,267,241 pregnant women, with 47,702 cases diagnosed with placental abruption. The study identified three categories of independent risk factors: The first category includes baseline maternal characteristics (18 items), such as maternal age ≥ 35 years, black race, low prepregnancy BMI (< 18.5 kg/m²), unmarried status, smoking during pregnancy, alcohol consumption, inadequate prenatal care (< 4 visits), marijuana use, multiple pregnancy, parity ≥ 3, anemia (hemoglobin < 11 g/dL), previous placental abruption, previous cesarean section, previous miscarriage, previous stillbirth, cervical incompetence, habitual abortions, and assisted reproductive technology. Among these, previous placental abruption (AOR = 2.72, 95% CI [2.16, 3.42]) was found to be the most significant risk factor. The second category includes pregnancy-related complications (7 items), such as preterm premature rupture of membranes, preeclampsia, small for gestational age, polyhydramnios, antepartum hemorrhage, gestational hypertension, and placenta previa. ...