Tailoring MXene-Heterometal-Doped MOF Composites via One-Step Room-Temperature Synthesis for Enhanced Electrochemical Detection of L -Tryptophan

作者：Li Zhang, Minjie Liang, Chao Li, Fengbo Li, Jianjiao Xin, Jiaxin Lang, Shaobin Li, Deqing Zhang · 发表于：Analytical Chemistry · 年份：2025 · DOI：10.1021/acs.analchem.4c06642 · 被引用次数：53 · 研究领域：MXene and MAX Phase Materials、Advanced biosensing and bioanalysis techniques、Electrochemical sensors and biosensors

L -Tryptophan ( l -Trp) is an essential amino acid that is critical to human health and biosynthetic processes. Hence, developing a simple and sensitive l -Trp sensor is of great importance. In this study, a Ce-doped MOF-199/Ti 3 C 2 T X MXene nanocomposite was developed to detect l -Trp. Density functional theory (DFT) calculation suggested that the doping of Ce can effectively enhance the electronic structure of MOF-199 and improve its adsorption capacity for l -Trp. Additionally, the integration of Ce-doped MOF-199 with Ti 3 C 2 T X MXene substantially improves the conductivity of MOFs, resulting in enhanced electrocatalytic activity of the nanocomposite material. The sensor exhibits a wide linear range (0.5–156.5 μM), low limit of detection (0.18 μM), and excellent selectivity. Further, the sensor possesses excellent reproducibility, repeatability, and long-term stability. It has been successfully used to detect l -Trp in milk with excellent recoveries (99.66–104.40%).