Lacticaseibacillus rhamnosus G7 alleviates DSS-induced ulcerative colitis by regulating the intestinal microbiota

作者：Jianlong Lao, Man Chen, Shuping Yan, Han Gong, Zhaohai Wen, Yanhong Yong, Dan Jia, Sang Lv, Wenli Zou, Junmei Li, Huiming Tan, Hong Yin, Xiangying Kong, Zengyuan Liu, Fucheng Guo, Xianghong Ju, Youquan Li · 发表于：BMC Microbiology · 年份：2025 · DOI：10.1186/s12866-025-03904-w · 被引用次数：9 · 研究领域：Probiotics and Fermented Foods、Inflammatory Bowel Disease、Gut microbiota and health

Ulcerative colitis (UC) is an intestinal disease caused by many factors that seriously harms the health of humans and animals. Probiotics are currently widely used to treat intestinal inflammation; however, different strains are specific, and the functions and effects of different strains are still unclear. In this study, Lacticaseibacillus rhamnosus G7 isolated from herdsmen yogurt was used. The results of the in vitro evaluation revealed that it had good tolerance and safety. In mice with colitis, G7 alleviated weight loss and colon shortening and reduced the DAI score. After G7 treatment, the levels of proinflammatory factors (IL-1β, IL-6 and TNF-α) and histopathological scores decreased, whereas the level of IL-10 increased. In addition, G7 rebalanced the intestinal microbial composition of colitis model mice by increasing the abundance of Faecalibaculum and decreasing the abundance of Bacteroides and Escherichia_Shigella. In summary, G7 has great potential in the prevention of colitis.