Amount and intensity of daily total physical activity, step count and risk of incident cancer in the UK Biobank

作者：Alaina H. Shreves, Scott R. Small, Rosemary Walmsley, Shing Chan, Pedro F. Saint‐Maurice, Steven C. Moore, Keren Papier, Kezia L. Gaitskell, Ruth C. Travis, Charles Edwards Matthews, Aiden Doherty · 发表于：British Journal of Sports Medicine · 年份：2025 · DOI：10.1136/bjsports-2024-109360 · 被引用次数：41 · 研究领域：Physical Activity and Health、Cancer survivorship and care、Nutritional Studies and Diet

OBJECTIVES: To investigate associations between daily physical activity, activity intensity and step counts with incident cancer risk. METHODS: Prospective analysis of UK Biobank participants who wore wrist-based accelerometers for 7 days, followed for cancer incidence (mean follow-up 5.8 years, SD 1.3). Time-series machine-learning models derived total physical activity, sedentary behaviour (SB), light-intensity physical activity (LIPA), moderate-vigorous-intensity physical activity (MVPA) and step counts. The outcome was a composite of 13 cancers previously associated with low physical activity in questionnaire-based studies. Cox proportional hazard models estimated HRs and 95% CIs, adjusted for demographic, health and lifestyle factors. We also explored associations of LIPA, MVPA and SB with cancer risk. RESULTS: Among 85 394 participants (median age 63 (IQR 56-68)), 2633 were diagnosed with cancer during follow-up. Compared with individuals in the lowest quintile of total physical activity (<21.6 milligravity units), those in the highest (34.3+) had a 26% lower cancer risk (HR=0.74 (95% CI 0.65 to 0.84)). After mutual adjustment, LIPA (HR=0.94 (95% CI 0.90 to 0.98)) and MVPA (HR=0.87 (95% CI 0.79 to 0.94)) were associated with lower risk, but SB was not. Similar associations were observed for substituting 1 hour/day of SB with LIPA or MVPA. Daily step counts were inversely associated with cancer, with the dose-response beginning to plateau at around 9 000 steps/day (HR=0....