Single-dose intranasal AdC68-vectored vaccines rapidly protect Syrian hamsters against lethal Nipah virus infection

作者：Mingqing Lu, Yanfeng Yao, Hang Liu, Yun Peng, Xuejie Li, Ge Gao, Miaoyu Chen, Xuekai Zhang, Lingjing Mao, Peipei Yang, Xiaoyu Zhang, Jing Miao, Zhiming Yuan, Jiaming Lan, Chao Shan · 发表于：Molecular Therapy · 年份：2025 · DOI：10.1016/j.ymthe.2025.03.032 · 被引用次数：6 · 研究领域：Virology and Viral Diseases、Viral Infections and Vectors、SARS-CoV-2 and COVID-19 Research

viral particles, offered a complete prophylactic protection window as few as 7 days before exposure to a lethal NiV-M challenge. Furthermore, passive transfer of sera from AdC68-F or AdC68-G immunized animals conferred complete protection against NiV-M infection in naive hamsters. These findings underscore the pivotal role of antigen-specific immunity in controlling NiV infection and highlight the potential of single-dose intranasal AdC68-based NiV vaccines for rapid protection during outbreaks. By providing rapid and effective protection, these vaccines could help reduce human-to-human transmission and aid in curbing NiV outbreaks.