Single‐shot T 2 mapping via multi‐slice information sharing based on switching modulation patterns multiple overlapping‐echo detachment imaging

作者：Chenyang Dai, Qinqin Yang, Jianjun Zhou, Liuhong Zhu, Liangjie Lin, Jiazheng Wang, Congbo Cai, Shuhui Cai · 发表于：Medical Physics · 年份：2025 · DOI：10.1002/mp.17778 · 被引用次数：2 · 研究领域：Advanced MRI Techniques and Applications、Functional Brain Connectivity Studies、Medical Imaging Techniques and Applications

Abstract Background Quantitative magnetic resonance imaging (qMRI) offers reliable biomarkers in clinic. Nevertheless, most qMRI methods are time‐consuming and sensitive to motion. Single‐shot multiple overlapping‐echo detachment (MOLED) magnetic resonance imaging can deliver robust T 2 mapping in about 100 ms with high motion tolerance. However, its spatial resolution is relatively low due to the limitations of signal‐to‐noise ratio (SNR) and echo‐train length. At the mean time, the number of echoes with different evolution times collected is usually limited, which is not conducive to T 2 mapping in high accuracy. Purpose To propose a novel method to improve the spatial resolution and quantification accuracy of single‐shot MOLED T 2 mapping. Methods A new method called switching modulation patterns multiple overlapping‐echo detachment imaging (SWP‐MOLED) was designed for multi‐slice information sharing via switching the k‐space modulation pattern of MOLED imaging. In the SWP‐MOLED pulse sequence, three different k‐space modulation patterns were devised, making the 12 main echoes of any three adjacent slices symmetrically and uniformly distributed around their k‐space centers to obtain diverse contrast weighting information. A multi‐slice fusion three‐dimensional spatial attention context‐guided U‐Net was trained with 3000/7000 synthetic data with geometric/brain patterns to efficiently learn the mapping relationship between SWP‐MOLED signals and T 2 maps. Experiments on nume...