Heart Failure, Dementia is Associated with Increased Stroke Severity, in-Hospital Mortality and Complications

作者：Lijun Zuo, Yanhong Dong, Yang Hu, Zixiao Li, Hongqiu Gu, Xingquan Zhao, Yongjun Wang · 发表于：ESC Heart Failure · 年份：2025 · DOI：10.1002/ehf2.15216 · 被引用次数：5 · 研究领域：Acute Ischemic Stroke Management、Heart Failure Treatment and Management、Dysphagia Assessment and Management

BACKGROUND: Heart failure (HF) is a risk factor for ischemic stroke. Cognitive impairment is very common in HF and stroke patients. Patients with HF have higher risk of developing dementia. However, there are limited studies investigating the characteristics, in-hospital mortality and complications of stroke patients with both HF and dementia. METHODS AND RESULTS: Patients in this study were from the China Stroke Center Alliance database. We divided patients into four groups: (A) stroke patients with dementia but no HF; (B) stroke patients with HF but no dementia; (C) stroke patients with both dementia and HF; (D) stroke patients without HF or dementia. We analysed the in-hospital mortality, and complications among the 4 groups. Outcomes include in-hospital mortality and in-hospital complications, including pneumonia, decubitus ulcer, pulmonary embolism, myocardial infarction, gastrointestinal bleeding and deep vein thrombosis (DVT). Multivariable logistic regression was performed to validate the association between HF, dementia, stroke and functional outcomes. Stroke patients with dementia and HF were older, and had a higher proportion of individuals with a history of strokeperipheral vascular disease and dyslipidaemia, and had a higher level of homocysteine, glycosylated hemoglobin and so on. Compared with group D (stroke patients without HF or dementia), all the other three groups have significantly higher proportion of in-hospital mortality and complications, such as pneu...