Oral Health Effects Among Adults Switching from Cigarettes to on!® Nicotine Pouches Compared to Those Who Continue Smoking.

作者：Jianmin Liu, Jeffery Edmiston, Jingzhu Wang, Kimberly R Milleman, Jeffery L Milleman, Abigale L Yoder, Maria Gogova, Mohamadi Sarkar · 发表于：PubMed · 年份：2025 · DOI：10.3290/j.ohpd.c_1925 · 被引用次数：6 · 研究领域：Smoking Behavior and Cessation、Oral microbiology and periodontitis research、Oral Health Pathology and Treatment

PURPOSE: The oral-health impact of nicotine pouches, an emerging category of oral tobacco products, has not been well studied. We evaluated the effects of switching from cigarettes to on!® nicotine pouches (test product, TPs) on oral-health endpoints among adult smokers (AS) relative to those who just continued smoking (CS). MATERIALS AND METHODS: In this randomised, open-label, parallel-group study, participants were randomly assigned to ad libitum use of 2, 4, or 8 mg nicotine TP or CS for 24 weeks. Oral-health endpoints, e.g., Modified Gingival Index (MGI), Gingival Bleeding Index (BI), and Lobene Stain Index (LSI)] were assessed at baseline and weeks 12 and 24, and compared between the TP and CS groups by using linear mixed model analysis for repeated measurements. RESULTS: n = 155 participants were randomised; 100 (TP = 48; CS = 52) completed week 12, and 85 (TP = 40; CS = 45) completed week 24 assessments. The TP group reduced their cigarette consumption by >90% by weeks 12 and 24 despite not intending to quit at baseline. Statistically significant reductions (p < 0.001) were observed for MGI and BI at weeks 12 (MGI = 20%; BI = 30%) and 24 (MGI = 28%; BI = 23%) in the TP group compared to the CS group, as well as compared to baseline. Statistically significant reductions (~60%, p < 0.001) were also observed for LSI in TP vs CS. No statistically significant changes were observed for LSI in the CS group at weeks 12 and 24 compared to baseline. DISCUSSION: The findings fro...