Phlorizin mitigates high glucose-induced metabolic disorders through the IIS pathway in Caenorhabditis elegans

作者：Qi Gu, Chenlu Wang, Han Huang, Dandan Wei, Lina Fu, Guosheng Liu, Quan Zhou, Jie Yang, Yujie Fu · 发表于：Food & Function · 年份：2025 · DOI：10.1039/d4fo04519j · 被引用次数：6 · 研究领域：Biomedical Research and Pathophysiology、Biochemical Acid Research Studies、Genetics, Aging, and Longevity in Model Organisms

mutant BQ1, the effect of phlorizin on lowering glucose and triglyceride levels was eliminated, meaning that AKT-1 was found to be a key target protein for phlorizin's hypoglycemic and lipid-lowering effects. Molecular docking results also indicated a strong interaction between phlorizin and AKT-1 protein. In summary, phlorizin alleviated metabolic disorders and gene expression imbalances induced by high glucose, and AKT-1 was first found as the key target protein for phlorizin achieving hypoglycemic and hypolipidemic effects.