Gender correlation between sleep duration and risk of coronary heart disease: a systematic review and meta-analysis

作者：Cun Li, Suxia Luo, Tianwei Liang, Dan Song, Junfen Fu · 发表于：Frontiers in Cardiovascular Medicine · 年份：2025 · DOI：10.3389/fcvm.2025.1452006 · 被引用次数：7 · 研究领域：Sleep and related disorders、Sleep and Work-Related Fatigue、Obstructive Sleep Apnea Research

Objective: The influence of extreme sleep duration on coronary heart disease (CHD) risk across genders remains a debated topic. Methods: This analysis gathers observational studies that explore association between varying sleep durations and CHD risks. Trend estimation employs generalized least squares, converting specific category risk estimates into relative risks (RR) per hour of sleep increase. A two-stage hierarchical regression model evaluates potential linear dose-response relationships. Data analysis utilizes random-effects restricted cubic spline models with four knots. Results: < 0.01). Notably, shorter sleep durations are linked to higher CHD risks in women, whereas longer durations are more consequential for men. The optimal sleep duration for minimizing CHD risk is between 7.0-8.0 h daily for men and 7.5-8.5 h for women. Conclusion: The influence of sleep duration on CHD risk differs significantly between genders. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/myprospero, identifier (CRD42023478235).