USP32 Promotes Colorectal Carcinoma Progression Through Activating NF ‐ κB Signalling Pathway

作者：Xiaofan Duan, Gaoshaer Yeerkenbieke, Siping Huang, Yanjun Feng · 发表于：Journal of Cellular and Molecular Medicine · 年份：2025 · DOI：10.1111/jcmm.70457 · 被引用次数：2 · 研究领域：Ubiquitin and proteasome pathways、Histone Deacetylase Inhibitors Research、Peptidase Inhibition and Analysis

Ubiquitin-specific protease 32 (USP32) plays a key role in cancer progression. However, its functions in colorectal carcinoma (CRC) are still unexplored. In our study, we explored the expression and clinical significance of USP32 in CRC as well as its relationship with the tumour microenvironment (TME). As a result, we found that USP32 is overexpressed in CRC and it is associated with poor outcomes in CRC patients. In addition, the expression of USP32 is significantly related to the activation of the NF-κB signalling pathway and the immune infiltrates of the TME. Wet experiments also confirmed that USP32 is critical for the proliferation, survival, and migration of CRC cells and tumour growth, which may be due to the activation of the NF-κB signalling pathway. In conclusion, targeting the USP32-NF-κB axis may be a novel treatment strategy for CRC patients.