Phase angle as a prognostic biomarker in metastatic colorectal cancer: A prospective trial

作者：Domina Kekez, Juraj Prejac, Gordan Adžić, Nikša Librenjak, Irma Goršić, Danijela Jonjić, Željko Krznarić, Goran Augustin, Stjepko Pleština · 发表于：World Journal of Gastrointestinal Oncology · 年份：2025 · DOI：10.4251/wjgo.v17.i4.103029 · 被引用次数：1 · 研究领域：Body Composition Measurement Techniques、Infrared Thermography in Medicine、Electrical and Bioimpedance Tomography

BACKGROUND: Colorectal cancer (CRC) represents a major global public health issue, ranking as the third most common cancer worldwide. Given the substantial prevalence of CRC, there is a critical need to identify precise prognostic and predictive biomarker tools for better treatment outcomes. Phase angle (PA) has been proposed as a prognostic marker in various non-malignant and malignant clinical conditions. AIM: To investigate the relationship between PA and survival outcomes in the first-line treatment of metastatic CRC (mCRC). METHODS: In this prospective observational study, we obtained data on patients who started first-line systemic chemotherapy from the beginning of 2020 until the end of 2022. The PA, assessed by the bioelectrical impedance analysis scale, was evaluated as a possible prognostic factor for treatment outcomes, which were measured as progression-free survival (PFS) and objective response rate (ORR). RESULTS: 10.5 months, respectively. No difference in ORR was observed. However, patients with PA ≥ 4.60° had a higher disease control rate. CONCLUSION: PA represents a novel and objective pre-chemotherapy prognostic factor to identify mCRC patients who are at increased risk of a worse survival outcome.