Hypertension and Atrial Fibrillation: A Frontier Review From the AF-SCREEN International Collaboration

作者：Teemu Niiranen, Renate B. Schnabel, Aletta E. Schutte, Yitschak Biton, Giuseppe Boriani, Claire Buckley, Alan C. Cameron, Albertino Damasceno, Søren Zöga Diederichsen, Wolfram Doehner, Yutao Guo, Richard Hobbs, Boyoung Joung, Graeme J. Hankey, Gregory Y.H. Lip, Trudie Lobban, Maja‐Lisa Løchen, Georges H. Mairesse, Amam Mbakwem, Peter A. Noseworthy, George Ntaios, Steven R. Steinhubl, George S. Stergiou, Jesper Hastrup Svendsen, Robert G Tieleman, Ji‐Guang Wang, Neil R Poulter, Jeff S. Healey, Ben Freedman · 发表于：Circulation · 年份：2025 · DOI：10.1161/circulationaha.124.071047 · 被引用次数：20 · 研究领域：Atrial Fibrillation Management and Outcomes、Blood Pressure and Hypertension Studies、Cardiac Imaging and Diagnostics

Hypertension is the leading modifiable risk factor for atrial fibrillation (AF) and is estimated to be present in >70% of AF patients. This Frontiers Review was prepared by 29 expert members of the AF-SCREEN International Collaboration to summarize existing evidence and knowledge gaps on links between hypertension, AF, and their cardiovascular sequelae; simultaneous screening for hypertension and AF; and the prevention of AF through antihypertensive therapy. Hypertension and AF are inextricably connected. Both are easily diagnosed, often silent, and frequently treated inadequately. Together, they additively increase the risk of ischemic stroke, heart failure, and many types of dementia, resulting in greater all-cause mortality, considerable disease burden, and increased health care expenditures. Automated upper arm cuff blood pressure devices with implemented technology can be used to simultaneously detect both hypertension and AF. However, positive screening for AF with an oscillometric blood pressure monitor still requires ECG confirmation. The current evidence suggests that high-risk individuals aged ≥65 years or with treatment-resistant hypertension could benefit from AF screening. Since antihypertensive therapy effectively lowers AF risk, particularly in individuals with left ventricular dysfunction, hypertension should be the key target for AF prediction and prevention rather than merely a comorbidity of AF. Nevertheless, several important gaps in knowledge need to be f...