Concussions Are Associated With Increases in Blood Pressure and Cardiovascular Risk in American-Style Football Athletes

作者：Austin Rim, Chang Liu, Mekensie Jackson, James Miller, Nkemka Chukwumerije, Rayan El Chami, Rand Ibrahim, Tanveer Kauser, Arthur Miller, Erin Simpson, W Larsen Vaughn, Angelo Galante, Craig B. Clark, Margot Putukian, Rachel Grashow, Aaron L. Baggish, Jonathan H. Kim · 发表于：JACC Advances · 年份：2025 · DOI：10.1016/j.jacadv.2025.101717 · 被引用次数：7 · 研究领域：Traumatic Brain Injury Research、Cardiovascular Effects of Exercise、Cardiovascular and Diving-Related Complications

BACKGROUND: Concussions sustained during American-style football (ASF) participation are common. Whether concussions are associated with cardiovascular risk is unknown. OBJECTIVES: The authors sought to determine whether concussions sustained during collegiate ASF participation lead to increases in systolic blood pressure (SBP) and acquired maladaptive cardiovascular phenotypes. METHODS: In a longitudinal and case-controlled analysis, ASF athletes at 2 National Collegiate Athletic Association Division-I programs were followed for up to 2 years with cardiovascular assessments including BP, echocardiography, and vascular applanation tonometry. ASF athletes who sustained clinically diagnosed concussions were compared to weight and player position-matched controls without concussions. RESULTS: Thirty-nine ASF athletes who sustained concussions (preconcussion baseline: [SBP] 129.6 ± 13.6 mm Hg) and 39 weight and player position-matched controls (preconcussion baseline: [SBP] 131.6 ± 13.1 mm Hg) were followed for 1 season postconcussion; 14 of these pairs were followed through 2 seasons. After 1 season, increased pulse wave velocity (PWV) (case Δ = 0.4 [0.2] m/s, P = 0.036; control Δ = -0.1 [0.1] m/s, P = 0.38) was observed among cases. Among the case and control pairs followed over 2 seasons, increased SBP (case Δ = 10.1 [3.6] mm Hg, P < 0.01; control Δ = 0.1 [3.2] mm Hg, P = 0.97) and diastolic blood pressure (case Δ = 8.2 [2.9] mm Hg, P < 0.01; control Δ = -4.1 [4.0] mm Hg, P = ...