Burden of tremor in Parkinson's disease: A survey study

作者：Robert A. Hauser, Tara Skarpaas, Andréa Merriam, Jason Rivera, Valmira Hoxhaj, Luigi M Barbato, Anita Chadha-Patel, Michelle Baladi · 发表于：Journal of Parkinson s Disease · 年份：2025 · DOI：10.1177/1877718x251329328 · 被引用次数：10 · 研究领域：Neurological disorders and treatments、Parkinson's Disease Mechanisms and Treatments、Botulinum Toxin and Related Neurological Disorders

Background Tremor is reported by people with Parkinson's disease (PwP) as being one of the most troublesome symptoms. Objective To characterize the PwP experience of tremor. Methods An internet-based survey of PwP living with tremor was conducted in the US, from September 2023 to March 2024. Results Survey responses from 634 respondents (PwP = 599; care partner = 35) were analyzed. Most (93%) PwP had tremor in their upper extremities and of these, 59% reported ≥2 tremor subtypes (rest/postural/kinetic). Overall, 24% reported little or no effect of medication and a further 25% reported that medication only somewhat improved their tremor. At least mild functional impairment due to tremor was reported by 65% of PwP and most indicated that ≥1 daily activity (83%), sensory experience (77%), or psychosocial function (92%) was impacted. Multinomial logistic regression analyses revealed that the odds [95%CI] of reporting severe functional impairment due to tremor (vs. slight) were increased by worse tremor in the dominant hand (4.9 [1.36, 17.72]); presence of OFF-time (4.7 [1.22, 18.30]), number of body parts affected (2.0 [1.45, 2.88]) and lack of medication effect (1.6 [0.30, 8.22]). The presence of all three tremor subtypes was associated with increased odds of being “ very dissatisfied ” with quality of life (21.5 [2.51, 183.44]). Conclusions Results from this survey demonstrate that tremor in PD is often more than a rest tremor and frequently impacts function and activities of d...