Subpleural injection of gelatin sponge particles to reduce pneumothorax incidence in CT-guided lung biopsies: a retrospective single-center case-control study

作者：Ziyi Zhu, Ya-Qin Yun, Hao Li, Zhongqiang Qin, Zhen Qian, Yun Zhu, Shuhua Li, Bo Xie, Mu Yuan · 发表于：BMC Cancer · 年份：2025 · DOI：10.1186/s12885-025-13911-9 · 被引用次数：3 · 研究领域：Pleural and Pulmonary Diseases、Hemostasis and retained surgical items、Lung Cancer Diagnosis and Treatment

BACKGROUND: To evaluate the efficacy and safety of track sealing using subpleural injection of gelatin sponge particles in reducing the incidence of pneumothorax after percutaneous CT-guided lung biopsy. METHODS: This study conducted a retrospective analysis of 1,026 patients who underwent CT-guided lung biopsy at our center from January 2022 to July 2024. After propensity score matching (PSM) to minimize the impact of confounding variables like smoke, lesion diameter, and tract length, 338 patients were ultimately included and assigned to the sealant group (169 patients) or the non-sealing group (169 patients) according to whether using the gelatin sponge particles sealing after needle withdraw to the subpleural area. Clinical and operative characteristics data were collated from electronic medical records (EMR) and Picture Archiving and Communication Systems (PACS). A multivariable logistic regression analysis was conducted to identify predictors of pneumothorax. RESULTS: In the sealing group, the incidence of pneumothorax was 14.8%, whereas it was significantly higher in the non-sealing group at 23.7% (p < 0.05). There was no significant difference in the chest tube placement rates of 3% and 1.8% (p = 0.723). Importantly, no significant complications, such as air embolism, were observed in either group. A multivariate logistic regression analysis, using a propensity score-matched cohort, identified patient emphysema (OR = 2.35 [1.22-4.51], p = 0.01) and the tract length (O...