A meta‐analysis of adverse offspring health outcomes in patients with gestational diabetes mellitus

作者：Jiewen Guan, Junlan Qiu, Lingjun Li, Mengyu Fu, Meihua Zhang, Yanting Wu, Ying Xu, Hongmei Ding, Qinqin Gao · 发表于：Diabetes Obesity and Metabolism · 年份：2025 · DOI：10.1111/dom.16341 · 被引用次数：20 · 研究领域：Gestational Diabetes Research and Management、Pregnancy and preeclampsia studies、Bariatric Surgery and Outcomes

This study aims to comprehensively evaluate the association between gestational diabetes mellitus (GDM) and the risk of chronic diseases, including obesity, glycolipid metabolic disorders, neurodevelopmental conditions and cardiovascular diseases, in offspring through a systematic meta-analysis. By searching PubMed, Web of Science and Cochrane systematic review databases, relevant observational studies published from January 2010 to February 2024 were comprehensively retrieved, and the Newcastle-Ottawa Scale was used to assess the quality of the studies. Subgroup analyses were performed based on the country status, offspring age, screening method and diagnostic criteria of GDM. A meta-regression model was used to assess the potential impact of study characteristics on the combined effect odds ratio (OR). Sensitivity analysis was conducted to examine the impact of individual studies on the overall results. Additionally, Egger's test and funnel plot analysis were utilized to assess potential publication bias. This meta-analysis included 32 studies, encompassing a total of 3 310 217 participants (90 304 women with GDM and 3 219 913 controls). Offspring exposed to GDM exhibited significantly elevated risks of obesity and overweight (OR = 1.57, 95% confidence interval [CI] [1.35, 1.82]), diabetes (OR = 4.50, 95% CI [2.87, 7.70]), autism spectrum disorder (OR = 1.38, 95% CI [1.20, 1.59]) and intellectual disabilities (OR = 1.70, 95% CI [1.52, 1.90]). Furthermore, offspring of mothe...