An Integrated Janus Bioelectronic Bandage for Unidirectional Pumping and Monitoring of Wound Exudate

作者：Jing Wang, Jintao Ye, Zhuoheng Li, Xinwang Li, Yong Luo, Zhongzeng Zhou, Conghui Liu, Tailin Xu, Xueji Zhang · 发表于：Nano Letters · 年份：2025 · DOI：10.1021/acs.nanolett.4c06147 · 被引用次数：33 · 研究领域：Wound Healing and Treatments、Planarian Biology and Electrostimulation、Electrospun Nanofibers in Biomedical Applications

Single-functional wound dressings provide limited therapeutic benefits for chronic wound healing. Effective care for chronic wounds requires a multifunction that integrates exudate management, therapeutic treatment, and continuous monitoring. Here, we introduce an integrated Janus bioelectronic wound care bandage designed to achieve self-pumping exudate management via an electrospinning Janus dressing with opposite wettability, antibacterial properties through silver nanoparticles (AgNPs), and the monitoring of multiplex biomarkers in wounds via electrochemical sensors positioned on the drainage side. The limits of detection (LOD) of sensors are 0.15 mM for glucose, 6.85 μM for UA, and 60.76 mV/decade for pH (4-8), respectively. We demonstrated in mice full-thickness wound models that this bandage effectively promoted wound healing, achieving a wound closure rate of 90.35% on day 14, and monitored the dynamic changes of three biomarkers within wounds in situ over a period of 3 days.