Exosomal miR-92a-3p serves as a promising marker and potential therapeutic target for adenomyosis

作者：Wanqi Shao, Yayuan Yu, Jianzhang Wang, Zhiruo Qiu, Shuyan Mei, Tao Cheng, Yichen Chen, Weili Zhu, Xiuhui Li, Xuan Che · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-024-84608-5 · 被引用次数：6 · 研究领域：Endometriosis Research and Treatment、Extracellular vesicles in disease、Reproductive System and Pregnancy

This study aimed to elucidate the role of microRNA-92a-3p (miR-92a-3p) in the pathogenesis of adenomyosis. We examined how miR-92a-3p, found in exosomes derived from ectopic lesions, influences the behaviour of endometrial cells, dorsal root ganglion (DRG), and human umbilical vein endothelial cells (HUVECs) and explored its potential as a non-invasive biomarker. Our findings revealed that miR-92a-3p was significantly upregulated in exosomes derived from ectopic adenomyotic lesions. This upregulation correlated with enhanced migration and invasion of eutopic endometrial cells, DRG, and HUVECs. Furthermore, this study demonstrated a significant correlation between miR-92a-3p levels in urinary exosomes and the clinical symptoms of adenomyosis, suggesting its potential as a non-invasive biomarker for the disease. This study elucidated an exosomal signalling process involving miR-92a-3p that drives pathological infiltration and angiogenesis to promote adenomyosis progression. Our findings highlight upregulated miR-92a-3p in biofluid exosomes as a promising non-invasive biomarker for diagnosing and monitoring adenomyosis and unveil novel targets and strategies for improved clinical management.