Clinical characteristics of severe community-acquired pneumonia in children with virus mono-detection versus co-detection with bacteria

作者：Qian Chen, Yuejie Zheng, Heping Wang, Xiao‐Nan Li, Jiali Gu, Zihao Liu · 发表于：BMC Pulmonary Medicine · 年份：2025 · DOI：10.1186/s12890-025-03591-3 · 被引用次数：3 · 研究领域：Respiratory viral infections research、Pneumonia and Respiratory Infections、Antibiotic Use and Resistance

BACKGROUD: By analyzing the etiological distribution and clinical characteristics of severe community-acquired pneumonia in children with virus mono-detection and co-detection with bacteria and other pathogens, to explore the clinical characteristics that can help identify mixed infections, thereby providing a basis for the more precise use of antimicrobial drugs. METHODS: A retrospective study was conducted on hospitalized children aged 1 month to 14 years with severe community-acquired pneumonia who underwent bronchoscopy in Shenzhen Children's Hospital from January to December 2018. The distribution of 19 pathogens detected by nucleic acid detection in bronchoalveolar lavage fluid was analyzed. Clinical data of children were obtained from the hospital electronic patient dossiers. Data were analyzed to describe the difference between viral mono-detection and co-detection. METHODS: A retrospective study was conducted on hospitalized children aged 1 month to 14 years with severe community-acquired pneumonia who underwent bronchoscopy in Shenzhen Children's Hospital from January to December 2018. The distribution of 19 pathogens detected by nucleic acid detection in bronchoalveolar lavage fluid was analyzed. Clinical data of children were obtained from the hospital electronic patient dossiers. Data were analyzed to describe the difference between viral mono-detection and co-detection. RESULTS: A total of 479 children with severe community-acquired pneumonia were enrolled from ...