Associations between multiple ambient air pollutants, genetic risk, and incident mental disorders: An interaction study in the UK population

作者：Xiaoxin I Yao, Shengzhi Sun, Qian Yang, Xinning Tong, Chen Shen · 发表于：The Science of The Total Environment · 年份：2025 · DOI：10.1016/j.scitotenv.2025.179137 · 被引用次数：3 · 研究领域：Air Quality and Health Impacts、Climate Change and Health Impacts、Health, Environment, Cognitive Aging

Mental disorders can be triggered by genetic and environmental risk factors. Limited studies have explored the effects of long-term exposure to air pollution on mental disorders, and most of the studies have focused on individual air pollutants. This study aimed to examine the relationship between long-term exposure to multiple air pollutants and incident mental disorders, including depression, anxiety, and schizophrenia, and whether the associations were affected by genetic susceptibility. Participants in the UK Biobank with no history of mental disorders were followed from baseline (2006 to 2010) to October 31st, 2022. Cox regression was applied to evaluate the correlation between PM 2.5 absorbance, PM 2.5 , PM 2.5–10 , PM 10 , NO 2 , and NOx and any or specific mental disorders. Additive and multiplicative scales were used to measure the interaction between air pollution and schizophrenia polygenic risk score (PRS), depression PRS, or anxiety PRS on specific mental diseases. After a median of 13.36 years of follow-up on 252,376 participants, we observed per interquartile increase of PM 2.5 absorbance (0.32 per meter), PM 2.5 (1.28 μg/m 3 ), NO 2 (10.08 μg/m 3 ), and NO x (16.78 μg/m 3 ) were related to a 2–6 % higher risk of incident mental disorders. The HR (95 % CI) of incident mental disorder for the 2nd, 3rd, and 4th quartile of the air pollution score were 1.05 (1.01–1.18), 1.13 (1.09–1.18), and 1.14 (1.09–1.19), respectively, in comparison to the lowest level of the ...