The rumen microbiome and its metabolome together with the host metabolome regulate the growth performance of crossbred cattle

作者：Wei Zhao, Li-na Ma, Xue Lin, Qiufei Jiang, Feng Yuan, Suwan Wang, Jinli Tian, Xiaohua Tian, Yaling Gu, Juan Zhang · 发表于：BMC Genomics · 年份：2025 · DOI：10.1186/s12864-025-11465-5 · 被引用次数：7 · 研究领域：Ruminant Nutrition and Digestive Physiology、Gut microbiota and health、Reproductive Physiology in Livestock

BACKGROUND: Although it has been demonstrated that gastrointestinal microorganisms greatly influence livestock performance, the effect of gastrointestinal microorganisms on the growth performance of crossbred cattle remains unclear. Due to their superior production characteristics, understanding the impact of gastrointestinal microorganisms on the growth performance of crossbred beef cattle is of significant importance for improving farming efficiency. RESULT: In this study, healthy Simmental with similar birth date and weight were selected as dams, Simmental (Combination I), Belgian Blue (Combination II) and Red Angus (Combination III) were used as parents for crossbreeding. The progeny of the three combination crosses were measured for growth performance under identical conditions from birth rearing to 18 months of age (n = 30). Rumen fluid and plasma were collected for macro-genomic and non-targeted metabolomic analysis (n = 8). The results showed that Combination II was superior to Combination I and Combination III in body weight (BW) and body height (BH) (P < 0.05). Mycoplasma, Succinivibrio, Anaerostipes, Methanosphaera, Aspergillus, and Acidomyces were significantly increased in the rumen of Combination II (P < 0.05), whereas differentially expressed metabolites (DEMs) 9,10,13-Trihome (11), 9,12,13-Trihome and 9(10)-Epome, and 9(S)-Hpode were reduced in abundance. In addition, plasma DEM PC (14:0/P-18:1(11Z)), PC (16:0/0:0), and PC (17:0/0:0) were down-regulated in com...