Effect of myo-inositol supplementation in mixed ovarian response IVF cohort: a systematic review and meta-analysis

作者：Jianeng Zhang, Huanhuan Zhang, Wenjing Zhou, Meiyan Jiang, Xian-Hua Lin · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1520362 · 被引用次数：9 · 研究领域：Ovarian function and disorders、Reproductive Biology and Fertility、Assisted Reproductive Technology and Twin Pregnancy

Objective There has been substantial research conducted recently on the effect of myo-inositol (MI) on human reproduction. However, it still remains ambiguous about the therapeutic efficacy of MI in infertile women undergoing in vitro fertilization embryo transfer (IVF-ET). This systematic review and meta-analysis was carried out to investigate the efficacy of MI on IVF outcomes. Methods Literatures were searched in the PubMed, Web of Science, Cochrane Library, ScienceDirect and Wanfang databases. The methodological quality was assessed using the Cochrane Risk of Bias tool. Data were pooled using a random- or fixed-effects model according to study heterogeneity. The results are expressed as odds ratio (OR) or mean difference (MD) with 95% confidence intervals (CIs). Heterogeneity was measured by the I 2 statistic. The protocol was prospectively registered with PROSPERO (CRD42024582149). Results Eleven eligible studies with 981 participants reported the IVF outcomes of the MI group versus the control group. The synthesis results showed that the metaphase II (MII) oocyte rate was higher in the MI group than in the control group (OR 1.55, 95% CI 1.04-2.31, P =0.03). For polycystic ovary syndrome (PCOS) women, as well as non-obese PCOS women, a statistically significant improvement in MII oocyte rate were assumed after taking MI (OR 1.97, 95% CI 1.20-3.25, P <0.01; OR 1.92, 95% CI 1.09-3.37, P =0.02) while there is no statistically significant advancement showed in the poo...