Colorectal cancer: highlight the clinical research current progress

作者：Meng Wang, Chaojing Zheng, Zitong Wang, Ruifen Li, Weiyuan Zhang, Yuchen Zhong, Hongyu Wu, Qian Zhang, Dong Han, Yuping Zhu, Guiyu Wang · 发表于：Holistic Integrative Oncology · 年份：2025 · DOI：10.1007/s44178-025-00152-w · 被引用次数：14 · 研究领域：Colorectal Cancer Surgical Treatments、Intraperitoneal and Appendiceal Malignancies、Colorectal Cancer Treatments and Studies

Abstract Colorectal cancer (CRC) is a highly prevalent malignancy and a leading cause of cancer-related mortality globally, necessitating the exploration of innovative diagnostic and therapeutic strategies alongside conventional approaches such as surgery, chemotherapy, and radiotherapy which exhibit inherent limitations. This review systematically examines recent advancements in CRC research, particularly focusing on early diagnostic methodologies, novel surgical techniques, advancements in radiotherapy and chemotherapy, as well as the burgeoning fields of immunotherapy and targeted therapies. A comprehensive search of the PubMed database was conducted to collate key clinical studies published over the last three years in order to assess the current landscape of CRC management. The results emphasize the paramount importance of early diagnosis and innovative surgical strategies while highlighting significant progress in radiotherapy and chemotherapy, with immunotherapy and targeted treatments emerging as promising avenues. Notably, the increasing incidence of aggressive early-onset colorectal cancer (EO-CRC) reinforces the urgent need for effective screening and prevention frameworks, supplemented by interdisciplinary treatment teams that are crucial for optimal patient management. Enhanced pathological diagnosis is vital for informing adjuvant chemotherapy decisions, and ongoing advancements in surgical methods and systemic therapies are contributing to improved patient outc...