Morphology and biomechanical index predict the rupture location and rupture risk of abdominal aortic aneurysm

作者：Tinghua Liu, Tao Hu, Wei-Ting Lu, Yue Yu, Songren Xue, Kemin Wu, Yu Liu, Jing Lin, Harrison X. Bai, Zhong Yun, Wei Wang · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-94828-y · 被引用次数：11 · 研究领域：Aortic aneurysm repair treatments、Cardiac, Anesthesia and Surgical Outcomes、Vascular Procedures and Complications

The integration of biomechanical and morphological analyses holds tremendous potential for assessing the rupture risk of abdominal aortic aneurysms (AAA). We employed a one-way fluid-structure interaction (FSI) model to distinguish between ruptured AAA (RAAA) and asymptomatic intact AAA (IAAA), focusing on morphological and computational fluid dynamics (CFD) indices. Patient groups with ruptured RAAA and asymptomatic IAAA were matched by diameter, age, and sex. AAA morphology was analyzed via CT segmentation, and biomechanical indices-including wall shear stress (WSS), peak wall stress (PWS), maximum deformation (MD), and other indices-were determined using FSI analysis. Statistical comparisons were performed using paired t-tests or Wilcoxon rank sum tests. Multivariate and LASSO regression analyses identified predictive factors, and a nomogram was developed. Model accuracy was assessed using the area under the curve (AUC). In our study with 66 RAAA and 66 asymptomatic IAAA patients, the tortuosity of the RAAAs was 1.4 times that of the asymptomatic IAAAs (P = 0.0005). The PWS, MD and peak wall rupture index (PWRI) of the RAAAs was 1.18, 1.32 and 1.27 times that of the asymptomatic IAAAs (P = 0.0158, 0.0036, 0.0071). The MD position demonstrated high consistency with RAAA rupture locations (94.12%). Four variables were selected for a nomogram, predicting AAA rupture with an AUC of 0.7604 (95% CI 0.6653-0.8556) and an internal validation AUC of 0.8051 (95% CI 0.6400-0.9703). I...