Comparing analgesic effects of temporal interference stimulation on ventral posterolateral thalamus and high-definition transcranial alternating current stimulation on sensorimotor cortex during sustained experimental pain

作者：Tianzhe Jia, Jiahui Xia, Chuan Zhang, Baijintao Sun, Kai Yuan, Tian Liu, Xiaoxue Xu, Jixin Liu · 发表于：Brain stimulation · 年份：2025 · DOI：10.1016/j.brs.2025.03.013 · 被引用次数：4 · 研究领域：Transcranial Magnetic Stimulation Studies、Neuroscience and Neural Engineering、Pain Mechanisms and Treatments

The quest for non-invasive, effective, and safe pain relief methods has driven extensive research. The sensorimotor cortex (SM1) is essential for pain localization, processing signals from the thalamus, particularly the ventral posterolateral nucleus (VPL), which is crucial for somatic pain perception [1]. While deep brain stimulation (DBS) targeting the VPL has shown significant long-term pain reduction [2], its invasive nature often deters patients. Transcranial temporal interference stimulation (tTIS) presents a promising non-invasive alternative.