CDH17-targeting CAR-NK cells synergize with CD47 blockade for potent suppression of gastrointestinal cancers

作者：Liuhai Zheng, Youbing Ding, Xiaolong Xu, Huifang Wang, Guangwei Shi, Yang Li, Yuanqiao He, Yue Gong, Xiaodong Zhang, Jinxi Wei, Zhiyu Dong, Jiexuan Li, Shan‐Chao Zhao, Rui Hou, Wei Zhang, Jigang Wang, Zhijie Li · 发表于：Acta Pharmaceutica Sinica B · 年份：2025 · DOI：10.1016/j.apsb.2025.03.039 · 被引用次数：11 · 研究领域：Immune Cell Function and Interaction、Phagocytosis and Immune Regulation、Immunotherapy and Immune Responses

) axis inhibitor CV1, likely through augmented macrophages activation and an increase in M1-phenotype macrophages in the tumor microenvironment. Collectively, our findings suggest that CDH17-targeting CAR-NK cells are a promising strategy for GI cancers. The combination of CDH17-CAR-NK cells with CV1 emerges as a potential combinatorial approach to overcome the limitations of CAR-NK therapy. Further investigations are warranted to speed up the clinical translation of these findings.