Association between gestational diabetes mellitus and offspring health: a two-sample mendelian randomization study

作者：Mi Yan, Zhengdong Chen, Jia Tang, Xinyu Duan, Wenjie Peng, Rui Liu, Wanwei Li, Zhangxue Hu, Yanfei Liu · 发表于：BMC Pregnancy and Childbirth · 年份：2025 · DOI：10.1186/s12884-025-07423-4 · 被引用次数：7 · 研究领域：Gestational Diabetes Research and Management、Genetic Associations and Epidemiology、Pancreatic function and diabetes

Gestational diabetes mellitus (GDM) constitutes a significant contributor to maternal and fetal morbidity, which is observed to be associated with future risks of offspring health. Nevertheless, it is essential to acknowledge that observational findings may be susceptible to residual confounding and bias. To investigate the association of GDM with offspring health, a genome-wide genetic association study employing Mendelian Randomization (MR) is conducted between May 31 and November 30, 2023. The inverse-variance-weighted (IVW) is utilized in the primary analysis stage. The study data of the majority patients are European ancestry, which are sourced from the IEU open genome-wide association study project. Genetically predicted GDM is associated with an increased risk of various short- and long-term health problem in offspring. For fetal and neonatal conditions, GDM is linked to an elevated risk of preterm delivery [ odd ratio (OR) = 1.150, false discovery rate (FDR)-adjusted P IVW = 0.009] and placental disorders (OR = 2.143, FDR-adjusted P IVW = 0.028). In respiratory diseases, it is associated with a higher likelihood of influenza (OR = 1.175, FDR-adjusted P IVW = 0.008), bacterial pneumonia (OR = 1.141, FDR-adjusted P IVW = 0.008), congenital malformations of the respiratory system (OR = 1.673, FDR-adjusted P IVW = 0.033), influenza with pneumonia (OR = 1.078, FDR-adjusted P IVW = 0.008), and need for non-invasive ventilation (OR = 1.265, FDR-adjusted P IVW = 0.028). In te...