Associations of body mass index and remnant cholesterol with hyperuricemia in patients with hypertension

作者：Wei Zhou, Tao Wang, Lingjuan Zhu, Yumeng Shi, Chao Yu, Huihui Bao, Xiaoshu Cheng · 发表于：BMC Endocrine Disorders · 年份：2025 · DOI：10.1186/s12902-025-01902-7 · 被引用次数：5 · 研究领域：Gout, Hyperuricemia, Uric Acid、Diet, Metabolism, and Disease、Diabetes, Cardiovascular Risks, and Lipoproteins

BACKGROUND: There is a paucity of prior research on residual cholesterol (RC) and hyperuricemia, and it remains unclear whether body mass index (BMI) functions as a mediating factor between them or intensifies lipid metabolic dysregulation, thereby elevating the risk of hyperuricemia. This study aims to investigate whether BMI mediates the association between RC and hyperuricemia, as well as the interaction or joint effect of BMI and RC on hyperuricemia. METHODS: This is a cross-sectional study, involving a total of 14,218 hypertensive patients. Exposure factors include RC and BMI. The outcome was Hyperuricemia, defined as serum uric acid (SUA) ≥ 420 µmol/L. Multivariable logistic regression models and causal mediation analysis were used to examine the association between RC and BMI and the prevalence of hyperuricemia. RESULTS: A total of 14,218 hypertensive patients were enrolled in this cross-sectional study, comprising 6,713 (47.2%) males, with a mean age of 63.8 (9.36) years. The prevalence of diabetes mellitus was found to be 10.4% (1,473), while hyperuricemia accounted for approximately 44.4% (6,319). The results show that there is a linear positive correlation between RC and hyperuricemia (P for trend < 0.01). RC and BMI only had significant additive interaction on hyperuricemia, but there was no multiplicative interaction (Additive: RERI = 0.45, 95%CI: 0.13-0.78; Multiplicative, OR = 1.09, 95% CI 0.92-1.3, P = 0.308). There are direct and indirect effects between RC a...