Association between endocrine disrupting chemicals exposure and diabetic kidney disease in adults: A national cross-sectional NHANES study

作者：Xinru Li, Xiaoang Ye, Liang Xu, Hongyu Chen · 发表于：Ecotoxicology and Environmental Safety · 年份：2025 · DOI：10.1016/j.ecoenv.2025.118044 · 被引用次数：8 · 研究领域：Per- and polyfluoroalkyl substances research、Effects and risks of endocrine disrupting chemicals、Toxic Organic Pollutants Impact

BACKGROUND: Diabetic kidney disease (DKD) is a global public health concern. Environmental factors are increasingly recognized as significant risk factors that cannot be overlooked, and certain environmental pollutants exhibit endocrine-disrupting properties. Previous research on the association between endocrine-disrupting chemicals (EDCs) and DKD has been notably limited. METHODS: This study investigated the association between exposure to 25 EDC metabolites and DKD in 1421 U.S. adults from the 2015-2018 National Health and Nutrition Examination Survey (NHANES). We used logistic regression, restricted cubic spline regression, weighted quantile sum (WQS) regression, and bayesian kernel machine regression (BKMR) models to assess the association between individual and co-exposure to multiple EDCs and DKD. Subgroup analyses and interaction tests were performed to investigate whether this association was stable across the population. Additionally, mediation analysis was used to explore the mediating role of serum globulins in the association between Pb exposure and DKD. RESULTS: In logistic regression models, N-Acetyl-S-(2-hydroxypropyl)-L-cysteine (2HPMA), N-Acetyl-S-(4-hydroxy-2-butenyl)-L-cysteine (MHBMA3), Phenylglyoxylic acid (PGA), and lead (Pb) were significantly positively associated with diabetes. Restricted cubic spline (RCS) analyses also revealed significant non-linear positive associations between 2HPMA, MHBMA3, and DKD. Perfluorohexane sulfonic acid (PFHxS), n-perf...