Sprayed hyaluronic acid based multidrug composite hydrogel for postoperative colorectal cancer ultra-efficient long-lasting multi-stage immuno-chemo synergistic therapy

作者：Ya Wang, Xiaojiang Zhang, Yujie Zhang, Feiyu Shi, Siyuan Du, Zhe Zhang, Chenyu Zhao, Siyuan Luo, Pengqian Wang, Daocheng Wu, Junjun She · 发表于：Materials Horizons · 年份：2025 · DOI：10.1039/d5mh00108k · 被引用次数：20 · 研究领域：Cancer Research and Treatments、Immunotherapy and Immune Responses、Cancer, Stress, Anesthesia, and Immune Response

experiments demonstrated that the composite hydrogel effectively eliminates residual tumors, ensuring a 100% survival rate without recurrence for 80 days in treated mice. Furthermore, it inhibits peritoneal metastasis and completely eradicates intraperitoneal tumors within 20 days. The ICP@PDA NPs@composite hydrogel represents a promising therapeutic platform for postoperative colorectal cancer treatment and metastasis prevention.