The impact of HBV, HCV, or syphilis infections on embryo and pregnancy outcomes in couples undergoing IVF treatment: a matched cohort study

作者：Fang Liu, Zheng Wang, Ying Song, Tian Tian, Rong Li, Jie Qiao, Shuo Huang, Yuan‐Yuan Wang · 发表于：Human Reproduction Open · 年份：2025 · DOI：10.1093/hropen/hoaf015 · 被引用次数：3 · 研究领域：Syphilis Diagnosis and Treatment、Reproductive tract infections research、Adolescent Sexual and Reproductive Health

STUDY QUESTION: Do infectious diseases (hepatitis B virus [HBV], hepatitis C virus [HCV], and syphilis) impact embryo quality, pregnancy, and neonatal outcomes following a complete IVF cycle? SUMMARY ANSWER: Infections with HBV, HCV, or syphilis do not have detrimental impacts on live birth rates or neonatal outcomes in couples following a complete IVF cycle. WHAT IS KNOWN ALREADY: Maternal or paternal infections with HBV, HCV, or syphilis may decrease the clinical pregnancy rate, result in poorer embryo outcomes, and lower offspring birth weight. However, there is significant controversy regarding these effects across existing studies, highlighting the need for further research. STUDY DESIGN SIZE DURATION: This is a retrospective matched cohort study. Data were obtained from the clinical database of couples who underwent IVF treatment at a single academically affiliated fertility clinic from January 2011 to December 2019, with follow-up extending to December 2020. Out of 180 666 complete cycles recorded, 2443 cycles fulfilled our inclusion criteria. PARTICIPANTS/MATERIALS SETTING METHODS: In cycles that fulfilled our inclusion criteria, there were 1997 cycles in the HBV study group, 154 cycles in the HCV study group, and 292 cycles in the syphilis study group. Each study cycle was paired with four controls based on participant age and the timing of IVF treatment, resulting in 7988 controls for the HBV group, 616 controls for the HCV group, and 1169 controls for the syphilis ...