Light-Responsive Hydrogel with Nano-Microstructures for Bacteria Eradication and Tumor Therapy

作者：Hanyin Hu, Zhuoming Xu, Jintao Liu, Haodong Hu, Haiyang Yang, Jun Ma, Jiayi Chen, Hongwei Xu, Zhenhai Cai, Xiaoguang Wang, Huanhuan Luo, Gang Chen · 发表于：ACS Applied Nano Materials · 年份：2025 · DOI：10.1021/acsanm.5c01116 · 被引用次数：6 · 研究领域：Nanoplatforms for cancer theranostics、Graphene and Nanomaterials Applications、Nanoparticle-Based Drug Delivery

The insufficient immunogenicity of the tumor microenvironment coupled with intratumoral bacteria are important causes of poor prognosis in osteosarcoma patients. The strategy for eliminating intratumoral bacteria and enhancing the immunogenicity of the tumor microenvironment is key to improving the therapeutic effect in osteosarcoma treatment. In this study, light-responsive hydrogel with nano-microstructures was constructed by microfluidic technology, enabling targeting the eradication of tumor bacteria and optically controlled programmed reconstruction of tumor microenvironment, which was composed of a hyaluronic acid-coated microshell and a polyadenylation drug-loaded mesoporous silica nanoparticles core modified by bacteria-targeting LPS antibody and heat-responsive plate. This study aims to promote the selective retention and photoresponsive release of drugs in osteosarcoma and finally realize the combined effect of antibacterial and antineoplastic photoimmunochemotherapy. The distinctive structure of the hydrogel with nano-microstructures enables inhibiting the progression of osteosarcoma, simultaneously eliminating bacteria and enhancing the immunogenicity of the tumor microenvironment. In vitro and in vivo experiments showed that the hydrogel with nano-microstructures improved the therapeutic effect on osteosarcoma by eliminating intratumoral bacteria through the synergistic action of photoimmunochemotherapy. On the other hand, the hydrogel with nano-microstructures a...