Intestinal tissue-resident memory T cells: Characteristics, spatial heterogeneity, age-related dynamics, and roles in disease regulation

作者：Ruilan Yan, Dingjiacheng Jia, Yinliang Qi, Qiwen Wang, Shujie Chen · 发表于：Journal of Advanced Research · 年份：2025 · DOI：10.1016/j.jare.2025.03.021 · 被引用次数：6 · 研究领域：Immune Cell Function and Interaction、T-cell and B-cell Immunology、Neuroinflammation and Neurodegeneration Mechanisms

BACKGROUND: cells play a pivotal role in maintaining mucosal immunity, exhibiting phenotypic and functional heterogeneity in different intestinal compartments and in response to aging and pathological conditions. AIM OF REVIEW: cells provide avenues for targeted therapies in intestinal diseases, cancer immunotherapy, and interventions to delay intestinal aging.